Spontaneous activation of visual pigments in relation to openness/closedness of chromophore-binding pocket

JOURNAL ARTICLE published 10 February 2017 in eLife

Research funded by National Eye Institute (EY06837) | National Eye Institute (EY001157) | National Natural Science Foundation of China (31471053) | Antonio Champalimaud Foundation, Portugal (Antonio Champalimaud Vision Award) | Howard Hughes Medical Institute (International Student Research Fellowships)

Authors: Wendy Wing Sze Yue | Rikard Frederiksen | Xiaozhi Ren | Dong-Gen Luo | Takahiro Yamashita | Yoshinori Shichida | M Carter Cornwall | King-Wai Yau

Testosterone pulses paired with a location induce a place preference to the nest of a monogamous mouse under field conditions

JOURNAL ARTICLE published 30 March 2022 in eLife

Research funded by National Science Foundation (1355163) | Sigma Xi (Spring 2018)

Authors: Radmila Petric | Matina Kalcounis-Rueppell | Catherine A Marler

Importance of miRNA stability and alternative primary miRNA isoforms in gene regulation during Drosophila development

JOURNAL ARTICLE published 19 July 2018 in eLife

Research funded by National Research Foundation Singapore (NRF2011NRF-NRFF001-042) | National Institutes of Health (R01-GM083300) | Ministry of Education - Singapore (MOE2014-T2-2-039) | National University of Singapore (R-154-000-536-133) | National Institutes of Health (R01-NS083833) | National University of Singapore (R-154-000-562-112) | National University of Singapore (R-154-000-582-651)

Authors: Li Zhou | Mandy Yu Theng Lim | Prameet Kaur | Abil Saj | Diane Bortolamiol-Becet | Vikneswaran Gopal | Nicholas Tolwinski | Greg Tucker-Kellogg | Katsutomo Okamura

A Toll-receptor map underlies structural brain plasticity

JOURNAL ARTICLE published 18 February 2020 in eLife

Research funded by Biotechnology and Biological Sciences Research Council (BB/P004997/1) | Biotechnology and Biological Sciences Research Council (BB/R017034/1) | H2020 Marie Skłodowska-Curie Actions (NPN)

Authors: Guiyi Li | Manuel G Forero | Jill S Wentzell | Ilgim Durmus | Reinhard Wolf | Niki C Anthoney | Mieczyslaw Parker | Ruiying Jiang | Jacob Hasenauer | Nicholas James Strausfeld | Martin Heisenberg | Alicia Hidalgo

Single-cell analysis of the aged ovarian immune system reveals a shift towards adaptive immunity and attenuated cell function

JOURNAL ARTICLE published 25 April 2023 in eLife

Research funded by Israel Science Foundation (1619/20)

Authors: Tal Ben Yaakov | Tanya Wasserman | Eliel Aknin | Yonatan Savir

Molecular mechanisms that stabilize short term synaptic plasticity during presynaptic homeostatic plasticity

JOURNAL ARTICLE published 13 November 2018 in eLife

Research funded by National Institute of Neurological Disorders and Stroke (R35NS097212)

Authors: Jennifer M Ortega | Özgür Genç | Graeme W Davis

A homozygous loss-of-function CAMK2A mutation causes growth delay, frequent seizures and severe intellectual disability

JOURNAL ARTICLE published 22 May 2018 in eLife

Research funded by Agency for Science, Technology and Research (GODAFIT Strategic Positioning Fund)

Authors: Poh Hui Chia | Franklin Lei Zhong | Shinsuke Niwa | Carine Bonnard | Kagistia Hana Utami | Ruizhu Zeng | Hane Lee | Ascia Eskin | Stanley F Nelson | William H Xie | Samah Al-Tawalbeh | Mohammad El-Khateeb | Mohammad Shboul | Mahmoud A Pouladi | Mohammed Al-Raqad | Bruno Reversade

Functional hierarchy among different Rab27 effectors involved in secretory granule exocytosis

JOURNAL ARTICLE published 21 February 2023 in eLife

Research funded by Japan Society for the Promotion of Science (JP19H03449) | Japan Society for the Promotion of Science (JP20K06535) | Japan Society for the Promotion of Science (JP20K15742)

Authors: Kunli Zhao | Kohichi Matsunaga | Kouichi Mizuno | Hao Wang | Katsuhide Okunishi | Tetsuro Izumi

Multimeric single-domain antibody complexes protect against bunyavirus infections

JOURNAL ARTICLE published 21 April 2020 in eLife

Research funded by Innovative Medicines Initiative (ZAPI (grant agreement no. 115760)) | Ministerio de Ciencia Tecnología y Telecomunicaciones (Student Fellowship (PEM-066-2015-II)) | Universidad de Costa Rica (Student Fellowship (OAICE-CAB-05-56-2016))

Authors: Paul J Wichgers Schreur | Sandra van de Water | Michiel Harmsen | Erick Bermúdez-Méndez | Dubravka Drabek | Frank Grosveld | Kerstin Wernike | Martin Beer | Andrea Aebischer | Olalekan Daramola | Sara Rodriguez Conde | Karen Brennan | Dorota Kozub | Maiken Søndergaard Kristiansen | Kieran K Mistry | Ziyan Deng | Jan Hellert | Pablo Guardado-Calvo | Félix A Rey | Lucien van Keulen | Jeroen Kortekaas

Manganese is a physiologically relevant TORC1 activator in yeast and mammals

JOURNAL ARTICLE published 29 July 2022 in eLife

Research funded by Universidad de Sevilla (2020/00001326) | Junta de Andalucía (P20-RT-01220) | European Molecular Biology Organization (STF-8685) | Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (310030_166474/184671) | Ministerio de Ciencia, Innovación y Universidades (PGC2018-096244-B-I00) | Ministerio de Ciencia, Innovación y Universidades (FPU19/04914)

Authors: Raffaele Nicastro | Hélène Gaillard | Laura Zarzuela | Marie-Pierre Péli-Gulli | Elisabet Fernández-García | Mercedes Tomé | Néstor García-Rodríguez | Raúl V Durán | Claudio De Virgilio | Ralf Erik Wellinger

Single-cell chromatin accessibility profiling of glioblastoma identifies an invasive cancer stem cell population associated with lower survival

JOURNAL ARTICLE published 11 January 2021 in eLife

Research funded by Stand Up To Cancer Canada, Genome Canada, CIHR, OICR, AACR (SU2C-AACR-DT-19-15) | CIHR (TGH-158221) | CIHR (MFE 338954)

Authors: Paul Guilhamon | Charles Chesnelong | Michelle M Kushida | Ana Nikolic | Divya Singhal | Graham MacLeod | Seyed Ali Madani Tonekaboni | Florence MG Cavalli | Christopher Arlidge | Nishani Rajakulendran | Naghmeh Rastegar | Xiaoguang Hao | Rozina Hassam | Laura J Smith | Heather Whetstone | Fiona J Coutinho | Bettina Nadorp | Katrina I Ellestad | H Artee Luchman | Jennifer Ai-wen Chan | Molly S Shoichet | Michael D Taylor | Benjamin Haibe-Kains | Samuel Weiss | Stephane Angers | Marco Gallo | Peter B Dirks | Mathieu Lupien

Immunoproteasome functions explained by divergence in cleavage specificity and regulation

JOURNAL ARTICLE published 28 November 2017 in eLife

Research funded by National Institutes of Health (F32CA168150) | University of California, San Francisco (Program for Breakthrough Biomedical Research) | University of California, San Francisco (Enabling Technologies Advisory Committee) | National Institutes of Health (R21CA186077) | National Institutes of Health (R21AI133393) | National Institutes of Health (P41CA196276)

Authors: Michael B Winter | Florencia La Greca | Shirin Arastu-Kapur | Francesco Caiazza | Peter Cimermancic | Tonia J Buchholz | Janet L Anderl | Matthew Ravalin | Markus F Bohn | Andrej Sali | Anthony J O'Donoghue | Charles S Craik

Nanobody-directed targeting of optogenetic tools to study signaling in the primary cilium

JOURNAL ARTICLE published 24 June 2020 in eLife

Research funded by Deutsche Forschungsgemeinschaft (SPP 1926) | Deutsche Forschungsgemeinschaft (SPP 1726) | Deutsche Forschungsgemeinschaft (TRR83/SFB) | Deutsche Forschungsgemeinschaft (Germany's Excellence Strategy - EXC2151 - 390873048) | Deutsche Forschungsgemeinschaft (FOR2743) | Deutsche Forschungsgemeinschaft (Emmy Noether) | Boehringer Ingelheim Fonds (PhD fellowship) | Samarbeidsorganet Helse Midt-Norge (grant) | Deutsche Forschungsgemeinschaft (SFB894/TP-A22)

Authors: Jan N Hansen | Fabian Kaiser | Christina Klausen | Birthe Stüven | Raymond Chong | Wolfgang Bönigk | David U Mick | Andreas Möglich | Nathalie Jurisch-Yaksi | Florian I Schmidt | Dagmar Wachten

Design of novel cyanovirin-N variants by modulation of binding dynamics through distal mutations

JOURNAL ARTICLE published 6 December 2022 in eLife

Research funded by National Science Foundation (1715591) | Gordon and Betty Moore Foundation (1901709) | National Institutes of Health (1R21CA207832-01)

Authors: I Can Kazan | Prerna Sharma | Mohammad Imtiazur Rahman | Andrey Bobkov | Raimund Fromme | Giovanna Ghirlanda | S Banu Ozkan

Modeling Hsp70/Hsp40 interaction by multi-scale molecular simulations and coevolutionary sequence analysis

JOURNAL ARTICLE published 12 May 2017 in eLife

Research funded by Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (2012_149278) | Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (20020_163042/1) | Agence Nationale de la Recherche (ANR-14-ACHN-0016)

Authors: Duccio Malinverni | Alfredo Jost Lopez | Paolo De Los Rios | Gerhard Hummer | Alessandro Barducci

ADF and cofilin-1 collaborate to promote cortical actin flow and the leader bleb-based migration of confined cells

JOURNAL ARTICLE published 25 June 2021 in eLife

Research funded by Melanoma Research Alliance (688232) | American Cancer Society (RSG-20-019-01 - CCG)

Authors: Maria F Ullo | Jeremy S Logue

Importin-9 wraps around the H2A-H2B core to act as nuclear importer and histone chaperone

JOURNAL ARTICLE published 11 March 2019 in eLife

Research funded by National Institute of General Medical Sciences (U01GM98256-01) | National Institute of General Medical Sciences (R01GM083960) | National Institute of General Medical Sciences (P41GM109824) | National Institute of General Medical Sciences (R01GM112108) | University of Texas at Dallas (Start-up funds) | National Institute of General Medical Sciences (R01GM069909) | Welch Foundation (I-1532) | Leukemia and Lymphoma Society (Scholar Award) | University of Texas Southwestern Medical Center (Endowed Scholars Program)

Authors: Abhilash Padavannil | Prithwijit Sarkar | Seung Joong Kim | Tolga Cagatay | Jenny Jiou | Chad A Brautigam | Diana R Tomchick | Andrej Sali | Sheena D'Arcy | Yuh Min Chook

Cadherin clusters stabilized by a combination of specific and nonspecific cis-interactions

JOURNAL ARTICLE published 2 September 2020 in eLife

Research funded by National Institute of General Medical Sciences (1R01GM117104)

Authors: Connor J Thompson | Zhaoqian Su | Vinh H Vu | Yinghao Wu | Deborah E Leckband | Daniel K Schwartz

Tackling variants with antibodies

JOURNAL ARTICLE published 28 March 2022 in eLife

Authors: Elizabeth H Aitken | Stephen J Rogerson

The Na+ leak channel NALCN controls spontaneous activity and mediates synaptic modulation by α2-adrenergic receptors in auditory neurons

JOURNAL ARTICLE published 10 January 2024 in eLife

Research funded by National Institute of Neurological Disorders and Stroke (R35NS116798) | National Institute on Deafness and Other Communication Disorders (DC004450) | Japan Society for the Promotion of Science (KAKENHI 22K06838)

Authors: Tenzin Ngodup | Tomohiko Irie | Seán P Elkins | Laurence O Trussell