Adaptive biasing of action-selective cortical build-up activity by stimulus history

JOURNAL ARTICLE published 6 December 2023 in eLife

Research funded by Deutsche Forschungsgemeinschaft (projects DO1240-4-1) | Bundesministerium für Bildung und Forschung (project 01EW2007B) | Sonderforschungsbereich (SFB) 936 (178316478 - Z3) | Deutsche Forschungsgemeinschaft (DO1240_2-2)

Authors: Anke Braun | Tobias H Donner

Dally is not essential for Dpp spreading or internalization but for Dpp stability by antagonizing Tkv-mediated Dpp internalization

JOURNAL ARTICLE published 24 January 2024 in eLife

Research funded by The Swiss National Science Foundation (Ambizione grant (PZ00P3_180019)) | Universität Basel (Research Fund Junior Researchers) | Deutsche Forschungsgemeinschaft (Germany's Excellence Strategy (EXC-2189-Project ID 390939984))

Authors: Niklas Simon | Abu Safyan | George Pyrowolakis | Shinya Matsuda

Mouthparts of the bumblebee (Bombus terrestris) exhibit poor acuity for the detection of pesticides in nectar

JOURNAL ARTICLE published 18 December 2023 in eLife

Research funded by Biotechnology and Biological Sciences Research Council (BB/S000402/1) | Royal Society (NIF/R1/19368) | Natural Sciences and Engineering Research Council of Canada (PDF-546125-2020)

Authors: Rachel H Parkinson | Jennifer Scott | Anna L Dorling | Hannah Jones | Martha Haslam | Alex E McDermott-Roberts | Geraldine A Wright

Exploring the K+ binding site and its coupling to transport in the neurotransmitter:sodium symporter LeuT

JOURNAL ARTICLE published 25 January 2024 in eLife

Research funded by Danmarks Frie Forskningsfond (1030-00036B) | Lundbeck Foundation (R344-2020-1020) | Novo Nordisk Fonden (NNF19OC0058496) | Carlsbergfondet (CF20-0345)

Authors: Solveig G Schmidt | Andreas Nygaard | Joseph A Mindell | Claus J Loland

Higher ratio of plasma omega-6/omega-3 fatty acids is associated with greater risk of all-cause, cancer, and cardiovascular mortality: A population-based cohort study in UK Biobank

JOURNAL ARTICLE published 5 April 2024 in eLife

Research funded by National Institute of General Medical Sciences (R35GM143060)

Authors: Yuchen Zhang | Yitang Sun | Qi Yu | Suhang Song | J Thomas Brenna | Ye Shen | Kaixiong Ye

N-WASP-dependent branched actin polymerization attenuates B-cell receptor signaling by increasing the molecular density of receptor clusters

JOURNAL ARTICLE published 12 December 2023 in eLife

Research funded by National Institute of Allergy and Infectious Diseases (AI122205) | National Institute of General Medical Sciences (GM064625)

Authors: Anshuman Bhanja | Margaret K Seeley-Fallen | Michelle Lazzaro | Arpita Upadhyaya | Wenxia Song

Neuropeptide Y-expressing dorsal horn inhibitory interneurons gate spinal pain and itch signalling

JOURNAL ARTICLE published 25 July 2023 in eLife

Research funded by Wellcome Trust (102645/Z/13/Z) | Wellcome Trust (219433/Z/19/Z) | Biotechnology and Biological Sciences Research Council (BB/N006119/1) | Biotechnology and Biological Sciences Research Council (BB/P007996/1) | Medical Research Council (MR/S002987/1) | Medical Research Council (MR/T01072X/1) | Medical Research Council (MR/V033638/1)

Authors: Kieran A Boyle | Erika Polgar | Maria Gutierrez-Mecinas | Allen C Dickie | Andrew H Cooper | Andrew M Bell | Evelline Jumolea | Adrian Casas-Benito | Masahiko Watanabe | David I Hughes | Gregory A Weir | John S Riddell | Andrew J Todd

A gut feeling about arthritis

JOURNAL ARTICLE published 5 November 2013 in eLife

Authors: Diane Mathis

Pleiotropic effects of trisomy and pharmacologic modulation on structural, functional, molecular, and genetic systems in a Down syndrome mouse model

JOURNAL ARTICLE published 18 March 2024 in eLife

Research funded by KU Leuven (C24/17/061) | Marie-Marguerite Delacroix Foundation (Doctoral Fellowship)

Authors: Sergi Llambrich | Birger Tielemans | Ellen Saliën | Marta Atzori | Kaat Wouters | Vicky Van Bulck | Mark Platt | Laure Vanherp | Nuria Gallego Fernandez | Laura Grau de la Fuente | Harish Poptani | Lieve Verlinden | Uwe Himmelreich | Anca Croitor | Catia Attanasio | Zsuzsanna Callaerts-Vegh | Willy Gsell | Neus Martínez-Abadías | Greetje Vande Velde

Structural dynamics of the active HER4 and HER2/HER4 complexes is finely tuned by different growth factors and glycosylation

JOURNAL ARTICLE published 18 March 2024 in eLife

Research funded by National Institutes of Health (R35GM139636) | National Cancer Institute (U54AI170792) | Deutsche Forschungsgemeinschaft (GZ: TR 1668/1-1) | National Institutes of Health (1F30CA247147)

Authors: Raphael Trenker | Devan Diwanji | Tanner Bingham | Kliment A Verba | Natalia Jura

Sensitive remote homology search by local alignment of small positional embeddings from protein language models

JOURNAL ARTICLE published 15 March 2024 in eLife

Authors: Sean R Johnson | Meghana Peshwa | Zhiyi Sun

WRNIP1 prevents transcription-associated genomic instability

JOURNAL ARTICLE published 15 March 2024 in eLife

Research funded by Fondazione AIRC per la ricerca sul cancro ETS (Investigator grant 19971) | Fondazione AIRC per la ricerca sul cancro ETS (Investigator grant 17383)

Authors: Pasquale Valenzisi | Veronica Marabitti | Pietro Pichierri | Annapaola Franchitto

Immunomodulatory drug discovery from herbal medicines: Insights from organ-specific activity and xenobiotic defenses

JOURNAL ARTICLE published 15 November 2021 in eLife

Research funded by National Institutes of Health (GM131753)

Authors: Jue Shi | Jui-Hsia Weng | Timothy J Mitchison

Putting perception into action with inverse optimal control for continuous psychophysics

JOURNAL ARTICLE published 10 October 2022 in eLife

Research funded by Hessian Ministry of Higher Education, Science, Research and Art (The Adaptive Mind)

Authors: Dominik Straub | Constantin A Rothkopf

Evolving interpretable plasticity for spiking networks

JOURNAL ARTICLE published 28 October 2021 in eLife

Research funded by European Commission (604102) | European Commission (720270) | European Commission (785907) | Universität Heidelberg (Manfred Stärk Foundation) | European Commission (800858) | European Commission (945539)

Authors: Jakob Jordan | Maximilian Schmidt | Walter Senn | Mihai A Petrovici

Visualizing molecules of functional human profilin

JOURNAL ARTICLE published 6 June 2022 in eLife

Research funded by Sinsheimer Foundation (Scholar Award) | ALS Association (20-IIP-506) | National Institutes of Health (GM133485)

Authors: Morgan L Pimm | Xinbei Liu | Farzana Tuli | Jennifer Heritz | Ashley Lojko | Jessica L Henty-Ridilla

A frameshift in Yersinia pestis rcsD alters canonical Rcs signalling to preserve flea-mammal plague transmission cycles

JOURNAL ARTICLE published 3 April 2023 in eLife

Research funded by National Key R&D Program of China (2022YFC2303200) | National Natural Science Foundation of China (31700072) | National Natural Science Foundation of China (31670139) | National Natural Science Foundation of China (31800120) | Chinese Academy of Medical Sciences (Non-profit Central Research Institute Fund 2019HY310001) | Chinese Academy of Medical Sciences (Innovation Fund for Medical Sciences (CIFMS) 2021-I2M-1-043) | Fundamental Research Funds for the Central Universities (3332021092) | National Institutes of Health (Research Project Grant R01AI117016-01A1)

Authors: Xiao-Peng Guo | Hai-Qin Yan | Wenhui Yang | Zhe Yin | Viveka Vadyvaloo | Dongsheng Zhou | Yi-Cheng Sun

The landscape of regulatory genes in brain-wide neuronal phenotypes of a vertebrate brain

JOURNAL ARTICLE published 13 December 2021 in eLife

Research funded by Shanghai basic research field Project (18JC1410100) | Shanghai Municipal Science and Technology Major Project (2018SHZDZX05) | The National Key Research and Development Program of China (2020YFA0112700) | Strategic Priority Research Program of Chinese Academy of Science (XDB32000000) | National Natural Science Foundation of China (31871035)

Authors: Hui Zhang | Haifang Wang | Xiaoyu Shen | Xinling Jia | Shuguang Yu | Xiaoying Qiu | Yufan Wang | Jiulin Du | Jun Yan | Jie He

NMNAT promotes glioma growth through regulating post-translational modifications of P53 to inhibit apoptosis

JOURNAL ARTICLE published 17 December 2021 in eLife

Research funded by National Natural Science Foundation of China (82073888) | Science and technology support program for youth innovation in universities of Shandong (2019KJM009)

Authors: Jiaqi Liu | Xianzun Tao | Yi Zhu | Chong Li | Kai Ruan | Zoraida Diaz-Perez | Priyamvada Rai | Hongbo Wang | R Grace Zhai

Serial grouping of 2D-image regions with object-based attention in humans

JOURNAL ARTICLE published 13 June 2016 in eLife

Research funded by Nederlandse Organisatie voor Wetenschappelijk Onderzoek (VICI scheme, MaGW grant, 400-09-198) | Nederlandse Organisatie voor Wetenschappelijk Onderzoek (Brain and Cognition grant, 433-09-208) | Nederlandse Organisatie voor Wetenschappelijk Onderzoek (ALW 823-02-010) | European Research Council (PITN-GA-2011-290011, ABC) | European Research Council (ERC advanced grant, 39490, Cortic_al_gorithms) | European Research Council (604102, Human Brain Project)

Authors: Danique Jeurissen | Matthew W Self | Pieter R Roelfsema