A survey of new PIs in the UK

JOURNAL ARTICLE published 20 September 2019 in eLife

Authors: Sophie E Acton | Andrew JD Bell | Christopher P Toseland | Alison Twelvetrees

Wiskott Aldrich syndrome protein regulates non-selective autophagy and mitochondrial homeostasis in human myeloid cells

JOURNAL ARTICLE published 2 November 2020 in eLife

Research funded by Wellcome Trust (090233/Z/09/Z) | Wellcome Trust (201250/Z/16/Z) | National Institute for Health Research (Great Ormond Street Hospital for Children NHS Foundation Trust)

Authors: Elizabeth Rivers | Rajeev Rai | Jonas Lötscher | Michael Hollinshead | Gasper Markelj | James Thaventhiran | Austen Worth | Alessia Cavazza | Christoph Hess | Mona Bajaj-Elliott | Adrian J Thrasher

Augmentation of progestin signaling rescues testis organization and spermatogenesis in zebrafish with the depletion of androgen signaling

JOURNAL ARTICLE published 28 February 2022 in eLife

Research funded by National Key Research and Development Program of China (2018YFD0900205) | Chinese Academy of Sciences (Pilot Program A Project XDA24010206) | National Natural Science Foundation of China (31972779) | National Natural Science Foundation of China (31530077) | National Natural Science Foundation of China (31702027) | Youth Innovation Promotion Association of CAS (2020336) | State Key Laboratory of Freshwater Ecology and Biotechnology (2016FBZ05) | Youth Innovation Promotion Association (2020336)

Authors: Gang Zhai | Tingting Shu | Guangqing Yu | Haipei Tang | Chuang Shi | Jingyi Jia | Qiyong Lou | Xiangyan Dai | Xia Jin | Jiangyan He | Wuhan Xiao | Xiaochun Liu | Zhan Yin

Niche-specific genome degradation and convergent evolution shaping Staphylococcus aureus adaptation during severe infections

JOURNAL ARTICLE published 14 June 2022 in eLife

Research funded by National Health and Medical Research Council (GNT1105525) | National Health and Medical Research Council (GNT1196103)

Authors: Stefano G Giulieri | Romain Guérillot | Sebastian Duchene | Abderrahman Hachani | Diane Daniel | Torsten Seemann | Joshua S Davis | Steven YC Tong | Bernadette C Young | Daniel J Wilson | Timothy P Stinear | Benjamin P Howden

Combinations of maternal-specific repressive epigenetic marks in the endosperm control seed dormancy

JOURNAL ARTICLE published 24 August 2021 in eLife

Research funded by Vetenskapsrådet (2017-04119) | Knut och Alice Wallenbergs Stiftelse (2018-0206) | Human Frontier Science Program (LT000162/2018-L)

Authors: Hikaru Sato | Juan Santos-González | Claudia Köhler

Analysis of rod/cone gap junctions from the reconstruction of mouse photoreceptor terminals

JOURNAL ARTICLE published 26 April 2022 in eLife

Research funded by National Institute of Mental Health (RF1MH127343) | National Eye Institute (EY029408) | National Eye Institute (EY017836) | National Institute of Neurological Disorders and Stroke (P30NS061800) | National Eye Institute (P30EY028102)

Authors: Munenori Ishibashi | Joyce Keung | Catherine W Morgans | Sue A Aicher | James R Carroll | Joshua H Singer | Li Jia | Wei Li | Iris Fahrenfort | Christophe P Ribelayga | Stephen C Massey

Adverse childhood experiences and resilience among adult women: A population-based study

JOURNAL ARTICLE published 1 February 2022 in eLife

Research funded by Icelandic Centre for Research (Doctoral grant) | H2020 European Research Council (Consolidator grant grant number 726413) | Icelandic Centre for Research (Grant of excellence grant number 163362-051)

Authors: Hilda Björk Daníelsdóttir | Thor Aspelund | Edda Bjork Thordardottir | Katja Fall | Fang Fang | Gunnar Tómasson | Harpa Rúnarsdóttir | Qian Yang | Karmel W Choi | Beatrice Kennedy | Thorhildur Halldorsdottir | Donghao Lu | Huan Song | Jóhanna Jakobsdóttir | Arna Hauksdóttir | Unnur Anna Valdimarsdóttir

Nanobody repertoire generated against the spike protein of ancestral SARS-CoV-2 remains efficacious against the rapidly evolving virus

JOURNAL ARTICLE published 7 May 2024 in eLife

Research funded by National Institutes of Health (P41GM109824) | National Institutes of Health (R01GM083960) | American Lung Association (923055)

Authors: Natalia E Ketaren | Fred D Mast | Peter C Fridy | Jean Paul Olivier | Tanmoy Sanyal | Andrej Sali | Brian T Chait | Michael P Rout | John D Aitchison

Cadherin clusters stabilized by a combination of specific and nonspecific cis-interactions

JOURNAL ARTICLE published 2 September 2020 in eLife

Research funded by National Institute of General Medical Sciences (1R01GM117104)

Authors: Connor J Thompson | Zhaoqian Su | Vinh H Vu | Yinghao Wu | Deborah E Leckband | Daniel K Schwartz

Hippocampal place cell remapping occurs with memory storage of aversive experiences

JOURNAL ARTICLE published 19 July 2023 in eLife

Research funded by National Science Foundation (NeuroNex 1704708) | National Institute of Mental Health (RO1-MH062122)

Authors: Garrett J Blair | Changliang Guo | Shiyun Wang | Michael S Fanselow | Peyman Golshani | Daniel Aharoni | Hugh T Blair

Hematodinium sp. infection does not drive collateral disease contraction in a crustacean host

JOURNAL ARTICLE published 18 February 2022 in eLife

Research funded by Interreg (BlueFish) | Biotechnology and Biological Sciences Research Council (BB/P017215/1)

Authors: Charlotte E Davies | Jessica E Thomas | Sophie H Malkin | Frederico M Batista | Andrew F Rowley | Christopher J Coates

Design of novel cyanovirin-N variants by modulation of binding dynamics through distal mutations

JOURNAL ARTICLE published 6 December 2022 in eLife

Research funded by National Science Foundation (1715591) | Gordon and Betty Moore Foundation (1901709) | National Institutes of Health (1R21CA207832-01)

Authors: I Can Kazan | Prerna Sharma | Mohammad Imtiazur Rahman | Andrey Bobkov | Raimund Fromme | Giovanna Ghirlanda | S Banu Ozkan

Modeling Hsp70/Hsp40 interaction by multi-scale molecular simulations and coevolutionary sequence analysis

JOURNAL ARTICLE published 12 May 2017 in eLife

Research funded by Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (2012_149278) | Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (20020_163042/1) | Agence Nationale de la Recherche (ANR-14-ACHN-0016)

Authors: Duccio Malinverni | Alfredo Jost Lopez | Paolo De Los Rios | Gerhard Hummer | Alessandro Barducci

Functional links between sensory representations, choice activity, and sensorimotor associations in parietal cortex

JOURNAL ARTICLE published 20 October 2020 in eLife

Research funded by Alfred P. Sloan Foundation (FG-2016-6468) | Whitehall Foundation (2016-08-18) | Greater Milwaukee Foundation (Shaw Scientist Award) | National Institutes of Health (EY029438)

Authors: Ting-Yu Chang | Raymond Doudlah | Byounghoon Kim | Adhira Sunkara | Lowell W Thompson | Meghan E Lowe | Ari Rosenberg

Real-time experimental control using network-based parallel processing

JOURNAL ARTICLE published 7 February 2019 in eLife

Research funded by Alfred P. Sloan Foundation (FG-2016-6468) | Whitehall Foundation (2016-08-18) | National Institutes of Health (DC014305) | National Institutes of Health (EY029438) | Greater Milwaukee Foundation (Shaw Scientist Award)

Authors: Byounghoon Kim | Shobha Channabasappa Kenchappa | Adhira Sunkara | Ting-Yu Chang | Lowell Thompson | Raymond Doudlah | Ari Rosenberg

Early analysis of the Australian COVID-19 epidemic

JOURNAL ARTICLE published 13 August 2020 in eLife

Authors: David J Price | Freya M Shearer | Michael T Meehan | Emma McBryde | Robert Moss | Nick Golding | Eamon J Conway | Peter Dawson | Deborah Cromer | James Wood | Sam Abbott | Jodie McVernon | James M McCaw

Topoisomerase VI senses and exploits both DNA crossings and bends to facilitate strand passage

JOURNAL ARTICLE published 29 March 2018 in eLife

Research funded by National Institutes of Health (RO1 CA077373) | National Science Foundation (DGE 1106400)

Authors: Timothy J Wendorff | James M Berger

Molecular determinants of phase separation for Drosophila DNA replication licensing factors

JOURNAL ARTICLE published 24 December 2021 in eLife

Research funded by National Institute of General Medical Sciences (R01GM141045-01) | National Cancer Institute (R01CA030490) | National Institute of General Medical Sciences (F32GM116393) | Cancer Prevention and Research Institute of Texas (RR200070) | Welch Foundation (I-2074-20210327)

Authors: Matthew W Parker | Jonchee A Kao | Alvin Huang | James M Berger | Michael R Botchan

Sec17/Sec18 can support membrane fusion without help from completion of SNARE zippering

JOURNAL ARTICLE published 4 May 2021 in eLife

Research funded by National Institutes of Health (R35GM118037) | National Institutes of Health (R37MH63105)

Authors: Hongki Song | Thomas L Torng | Amy S Orr | Axel T Brunger | William T Wickner

Sam68 promotes self-renewal and glycolytic metabolism in mouse neural progenitor cells by modulating Aldh1a3 pre-mRNA 3'-end processing

JOURNAL ARTICLE published 15 November 2016 in eLife

Research funded by Telethon (GGP14095) | Associazione Italiana Ricerca sul Cancro (IG14581) | Telethon (GGP 12189)

Authors: Piergiorgio La Rosa | Pamela Bielli | Claudia Compagnucci | Eleonora Cesari | Elisabetta Volpe | Stefano Farioli Vecchioli | Claudio Sette